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While acetazolamide is the standard medical therapy, weight loss is also considered a first-line treatment

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This article provides a comprehensive review of DSIPs biological mechanisms, potential benefits, dosage considerations, comparative efficacy, and current research data

Sometimes this issue is fixed simply by optimizing buffers, for instance by increasing salt or detergent concentration, so that the interacting protein no longer binds to the GST only control, but still binds to your GST-fusion protein of interest