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The mutations that lead to abnormal hedgehog pathway activation and tumor formation are inactivating mutations of PTCH1 or activating mutations of SMOm

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Austin, M.D., who is a co-author of the Nature Medicine paper, said "Our center has brought pharmaceutical-scale chemical screening, informatics and medicinal chemistry to bear on neglected diseases that affect millions globally, but are not worked on by the pharmaceutical industry since they cannot generate the needed financial returns

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