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Retatrutides data set is still being generated

In this study, people with type 2 diabetes and both peripheral and autonomic diabetic neuropathy who took 1,000mcg of oral B12 for one year had significant improvements in all neurophysiological parameters, sudomotor function, pain score, and quality of life

2018 Nov;139:10-18

Diabetes adds another layer of risk, because high blood sugar can make nerves more fragile and easier to compress

A potentially novel target to treat obesity and type 2 diabetes is nicotinamide-N-methyltransferase (NNMT), a cytosolic enzyme with newly identified roles in cellular metabolism and energy homeostasis