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The finding of lower levels of H 2 O 2 in this study is in contrast to earlier reports where elevated levels of H 2 O 2 production were reported in immortalized renal proximal tubular epithelial cells from 4- to 8-week-old SHR, and renal cortical cells from 3-month but not 12-month-old SHR

17 to 20): In pathological situations, macrophages and neutrophils, recruited to a site of injury, are activated to produce NO as part of the inflammatory response