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A recent randomized study comparing structured lifestyle modification (a cornerstone in the currently recommended treatment of NASH) to liraglutide 3 mg/day without lifestyle modifications showed similar reductions in ALT and liver stiffness with no difference in bodyweight variations

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One of the simplest yet most impactful changes you can make is to increase your fluid intake

These considerations suggest that apelin is underexplored, not because of weak biology, but because pharmacologic refinement was insufficient at the time of early evaluation

AT-7687, a novel GIPR peptide antagonist, combined with a GLP-1 agonist, leads to enhanced weight loss and metabolic improvements in cynomolgus monkeys