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L-cells in the gut release GLP-1 that activates the GLP-1 receptors on the pancreatic beta cells (that release insulin) as well as send a message via the Vagus nerve to the appetite control center in the hypothalamus in the brain

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These conditions increase risk for GLP-1-related complications, but are not automatic contraindications

To understand how this evolving market might play out, this paper will address the following questions: What is the current state of the incretin mimetic market in diabetes and obesity, and how did we get here