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In brown adipocytes, ADRB3-mediated ERK1/2 activation depends entirely on the cAMP-PKA axis 38 , and consistent with this, we observed significantly lower levels of phosphorylated ADRB3 (Ser247) and ADCY6 (Ser574) in vaspin-treated brown adipocytes (Supplementary Data 3)

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While several agents, including standard anti-ulcer drugs, have been linked to stomach cell protection and cytoprotective effects [ 3 ] , achieving a comprehensive generalization of the concept has proven challenging