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Research profiles its selectivity for NNMT over other methyltransferases and establishes structure-activity relationships
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These are experimental patterns
Indications and Usage for Cyanocobalamin Cyanocobalamin is indicated for vitamin B 12deficiencies due to malabsorption which may be associated with the following conditions: Addisonian (pernicious) anemia Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacteria overgrowth, total or partial gastrectomy Fish tapeworm infestation Malignancy of pancreas or bowel Folic acid deficiency It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug Interactions), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue
The desensitisation procedure should be started by the 1/1001/1000 solutions of the drug target or the 1/101/1000 solutions of positive intradermal test dose and in increasing doses by doubling with 3090min intervals until the therapeutic dose is achieved.5 Desensitisation must be carried out in a hospital setting by experienced personnel with adequate resuscitation equipment readily available
