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This situation leads to neurodegeneration (cell death) in infarcted regions and global brain inflammation (Radak et al., 2017)

These outcomes are primarily due to mechanisms regulating appetite, delaying gastric emptying, and lowering overall energy consumption

In a study conducted by Shibata et al., it was observed that tocotrienol administration led to the suppression of hypoxia-inducible factor (HIF-1), a transcription factor known to induce the expression of vascular endothelial growth factor (VEGF) and initiate angiogenesis in the presence of low oxygen levels

The main difference is the route of administration

Antiangiogenic therapy for cancer: an update