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We find that those affected with stage 3 have the lowest overall levels of GPx3 and display non-overlapping 95% confidence intervals as compared to their unaffected siblings (95% CI Stage 3 [0.93 g/ml, 1.36 g/ml], 95% CI Unaffected [1.78 g/ml, 2.23 g/ml]) (Fig

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98 Similarly, the modification of the phosphate group in NMN allows its transportation to activate SARM1 in cells