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Thats why some physicians start patients on one before adding the second

Scanzello CR, Umoh E, Pessler F, et al

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Clin Sci 121:107117

[23] [21] Semaglutide also produced body weight reductions of 2.3 to 4.8 kg, attributed to appetite suppression and delayed gastric emptying, benefits observed even without intentional calorie restriction