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Among participants with obesity but without diabetes, treatment with tirzepatide was superior to treatment with semaglutide with respect to reduction in body weight and waist circumference at week 72

Mechanisms of action: mono, dual, triple Semaglutide: the pure GLP-1 Semaglutide is a synthetic analog of human GLP-1 modified to resist DPP-4 and bind albumin through a C18 fatty-acid chain

Weakness or imbalance creates impingement, abnormal tendon loading, and continued tissue damage

This means there is no established pharmacological mechanism by which semaglutide would be expected to cause spotting or bleeding between periods