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Furthermore, in three previous RCTs of non-pregnant hypertensive patients, with and without CVD, we demonstrated that intervention with low-dose riboflavin (16 mg/d) for 16 weeks resulted in a lowering of systolic blood pressure by up to 13 mmHg, specifically in those with the TT genotype (Reference Horigan, McNulty and Ward112Reference Wilson, Mcnulty and Ward114)