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These effects arise from both direct microbehost interactions. Dysbiosis markedly diminishes the physiological tolerance of intestinal tissues to ferroptosis, thereby compromising the intestinal barrier function and exacerbating colitis (114)

Wegovy is a weekly subcutaneous injection given at any time

Phase 3 trials (the TRIUMPH programme, registered on ClinicalTrials.gov) are currently underway, evaluating retatrutide across broader populations including those with cardiovascular disease, type 2 diabetes, and obesity-related complications

Injection site reactions are local effects, while dry mouth is a systemic one