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Tirzepatide may be preferred for: Patients seeking maximum weight loss Those who havent achieved goals with GLP-1 agonists alone Individuals with significant insulin resistance Patients without established cardiovascular disease Semaglutide may be preferred for: Patients with established heart disease needing CV protection Those who prefer oral medication options (Rybelsus) Individuals with insurance coverage specific to semaglutide Patients whove had good results with other GLP-1 medications Long-Term Considerations for Tirzepatide and Semaglutide Treatment Sustaining Weight Loss Research shows that both medications require continued use to maintain weight loss

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