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It's a physiological tug-of-war where your goals are the rope, and youre pulling against yourself

Studies of bariatric surgery consistently demonstrate bone density decreases following major weight loss, and similar patterns may occur with pharmacologically induced weight reduction

Grmayer ER, Schmidmeier W, Panzer S, Gadner H (1986) Toxicity of sequential high-dose ARA-C asparaginase treatment in childhood poor risk leukemia

Liver function is another important safety checkpoint: naltrexone is hepatically metabolized, as are many medications used alongside weight loss therapy

The GH pulse it generates is pulsatile and physiological in character rather than the sustained elevation seen with exogenous hGH