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Ongoing studies seek to investigate chemical analogs and mechanisms of action to identify lead drug candidates that can be developed for clinical translation

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The mechanisms of iron-overload-induced bone loss mainly include the increased osteoclastogenesis and bone resorption capacity of osteoclasts [131], lipid peroxidation accumulation and ferroptosis in osteoblasts [132]

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Diagnosis Demographic data were obtained for each subject from medical records at the time of the enrollment and included current age, sex and family history of hypertension and stroke