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Morphologically it is distinct from apoptosis, necrosis and pyroptosis: mitochondria shrink, their membranes become denser and cristae disappear, whereas nuclear architecture remains intact ( Figure 1 , the core mechanism of ferroptosis comprises three inter-locking events: perturbation of iron metabolism, build-up of lipid peroxides, and collapse of the glutathioneglutathione peroxidase 4 (GSHGPX4) antioxidant axis

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