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The process of protein S-glutathionylation has been found to be involved the regulation of metabolism, signal transduction, transcription, inflammation, physiological processes, and cytoskeletal organization

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On the contrary, microsomal GSTs, also known as MAPEG (membrane-associated proteins involved in eicosanoid and glutathione metabolism), are integral membrane proteins which are not evolutionary related to the other major classes

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This condition affects approximately one in three adults in the UK and exists in two main forms: non-alcoholic fatty liver disease (NAFLD) , which develops in people who drink little or no alcohol, and alcohol-related liver disease (ARLD) , caused by excessive alcohol consumption