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TNF- inhibitors The clinical effect of TNF- inhibitors on discogenic LBP has not been reported but has been investigated in disc-related diseases, such as sciatica (Table 2)

Figure 2 3.1 Neutrophils Neutrophil granulocytes are the first line of defense against inflammation in tissues, utilizing phagocytosis, degranulation, and generation of neutrophil extracellular traps (NETs) to combat pathogens

a 2025 literature review identified limited clinical evidence, including a retrospective study of 12 patients with knee pain and a Phase I trial in healthy volunteers whose results were not submitted

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