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Due to the unwanted erection-inducing effects of MT-II, the research team pursued the development of afemelanotide (originally named melanotan 1), which is more expensive to manufacture, but does not induce erections due to an inability to cross the blood-brain barrier

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GLP-1 receptor agonists mimic a gut hormone that regulates blood glucose, suppresses appetite, and slows gastric emptying

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The GLP-1 receptor agonists seem to be the victims of their own success