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This program uses daily sublingual tablets combined with habit coaching over a 90-day period

MGC026, which carries the TOPI inhibitor/exatecan payload SYNtecan E, was shown to have potent antitumor activity in B7H3+ patient-derived xenograft models of prostate cancer, and is currently undergoing a phase I clinical trial in patients with advanced solid tumors, including CRPC (NCT06242470) 108,109

This can possibly be explained by a hormonally lowered neuro-excitability threshold for these headache attacks 68

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Patients with very lean body composition or minimal abdominal fat should avoid upper-abdominal injection sites and instead focus on the thigh or upper arm, where subcutaneous tissue is more reliably present