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However, peripheral distribution decreases the efficacy of oral therapy, requiring high doses, which causes potential systemic side effects (e.g., neutropenia)

Liposomes encapsulated in dipotassium glycyrrhizinate have been used as an anti-inflammatory medication in the treatment of both acute and chronic dermatitis [411, 412]

doi: 10.1093/jn/132.5.897

Further, animal studies indicate that it may strengthen the gut-brain axis, improving feedback between the GI tract and the central nervous system to elicit systemic effects [2, 4, 11]

Both peptides demonstrate convergent effects on angiogenesis promotion and inflammatory modulation while maintaining distinct molecular targets and cellular mechanisms, suggesting potential synergistic therapeutic applications in regenerative medicine contexts