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The TCA cycle produces metabolites that contribute to epigenetic modification (Figure 2)

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Funding Miterko, Beckinghausen, Sillitoe: This work was supported by funds from Baylor College of Medicine (BCM) and Texas Childrens Hospital, BCM IDDRC Grant U54HD083092 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (The IDDRC Neuropathology and Neurobehavior Sub-Cores were used for anatomy and behavior), and by the National Institutes of Mental Health R01MH112143 to RVS, the National Institutes of Neurological Disorders and Stroke (NINDS) R01NS089664 and R01NS100874 to RVS

The problem with prolonged caloric deficit is that metabolic adaptation your body downregulates energy expenditure over time to resist the deficit

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