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The potential loss of essential homoeostatic astrocyte functions includes (i) down-regulation of glutamate uptake that disturbs circuit function and increases excitotoxic potential 141,142,143

The volume of distribution ranges from 0.33 to 0.47 L/kg and protein binding is significant, reaching approximately 50% 4 hours after the dose

doi:10.1016/j.diabres.2023.111079 82

Produced using controlled manufacturing processes and analytically verified to 99% purity, this formulation supports reliable performance in advanced laboratory research environments

41 The presence and severity of subclinical and clinical target organ damage is associated, in the setting of hypertension, with that of endothelial dysfunction