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Akaike, T

Whilst significant alterations in OCR and ECAR were demonstrated in normal rectal tissue biopsies treated with H 2 O vehicle control versus baseline, interestingly, no significant alterations in OCR or ECAR was demonstrated following metformin treatment, when compared to baseline ( Figures 6C, D )

This UL of 1,000 mg of vitamin E/day was based on the adverse effect of increased bleeding observed in rat studies (Wheldon et al., 1983