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15 In the first case, a longitudinal assessment demonstrates clear worsening in symptoms with taper or discontinuation of tirzepatide and clear improvement in symptoms with initiation or titration of tirzepatide

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and S.S.) worked independently to assess the titles and abstracts of the studies to determine whether they met the inclusion criteria

MariTide (AMG 133 / maridebart cafraglutide) is Amgens investigational, first-in-class bispecific molecule that combines GLP-1 receptor agonism with GIP-receptor antagonism using a peptide-antibody conjugate