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A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant

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According to the subcellular localization of GSH1, the GSH synthesis initiates in the plastids, but the predominant transcript, especially in the case of multiple GSH2 transcript populations, encodes a cytosolic GSH2, suggesting the second step occurs in the cytosol (Noctor et al., 2012)