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Lower carbohydrate days enhance fat oxidation while periodic higher days support thyroid function and leptin levels

Our findings are consistent with prior clinical trials, which reported substantial weight loss with tirzepatide across multiple dosing regimens, further supporting its superior efficacy comparing with single-receptor GLP-1 agonists (21, 22)

GLP-1 agonists may represent a paradigm shift: metabolic drugs with measurable effects on craving and reward circuitry