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Therefore, the two major effects that are enhanced by IGF-1 are FFA use by muscle and GH suppression

Lipids required for ATG8 lipidation and membrane extension are delivered to the phagophore via ATG2 and ATG9, where ATG9 acts as a seed to initiate lipid transfer by ATG2 that acts as a hose funneling lipids from relevant compartments (e.g., the ER) to the phagophore (5254, 7678) ( Figure 1 , panel 3)

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