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The double mutant pcs1pcs2 impaired in phytochelatin synthesis and the catabolism of glutathione conjugates 61,62 showed also a WT-like phenotype when exposed to AITC
[21] [3] Hepatic impairment is also relevant: vildagliptin, for example, should be avoided in patients with hepatic impairment, and liver function tests (LFTs) should be monitored during treatment as specified in its SmPC
Regulatory agencies require extensive clinical evidence before approval, and the absence of such data means safety and effectiveness remain uncertain
A standardized approach (like the guidelines in this article) can be included in lab SOPs (Standard Operating Procedures) for consistency
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