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While the passive technique focuses on drug and vehicle interaction and optimization to affect the stratum corneum structure, the active approach utilizes external energy to facilitate the transportation of drugs through the skin or by physically disrupting the outermost layer of the skin, known as the stratum corneum [230, 231]

This finding represents a typical feature of altered myelin morphology commonly observed after peripheral nerve injury

Nature 590 , 473479 (2021)

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If a person wishes to perform enemas at home, it may be safer for them to use fluids such as water or saline solution in place of coffee