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Decreased vitamin B12 absorption due to altered gut microbiota Potential for megaloblastic anemia in prolonged use Increased risk of neuropathy and other neurological complications Dose and Duration Considerations The risk of B12 deficiency with metformin depends on the dose and how long you take it

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Front Immunol 9:1363 Jaeger C, Tischkau SA (2016) Role of aryl hydrocarbon receptor in circadian clock disruption and metabolic dysfunction