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2a) and cysteine starvation (Supplementary Fig

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Rapid weight loss induced by GLP-1 therapy may alter thyroid hormone absorption and metabolic clearance, necessitating TSH checks every 6-8 weeks during the initial treatment phase

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The onset of mitotic catastrophe is intricately tied to the integrity of cell cycle checkpoints, particularly the G2/M checkpoint, which verifies that cells with fully replicated and undamaged DNA advance to mitosis