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Long-Term Use: Once dark circles improve, continue using to maintain results

Neurobiology of vitamin C: expanding the focus from antioxidant to endogenous neuromodulator

The key insight was that opening the cyclic structure at specific positions and introducing structural modifications could preserve activity at MC3R and MC4R while reducing activity at MC1R and MC5R

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Melatonin and its metabolites have extremely broad antioxidant actions, including the ability to neutralize superoxide anions (O 2 ), hydroxyl radicals ( OH), single oxygen (1O 2 ), hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), nitric oxide (NO), and peroxynitrite anions (ONOO )