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High neuronal synaptic Zn concentrations (up to 300 M) are present transiently in specific areas in rodent CNS (such as the hippocampal mossy fibers) after neuronal hyperexcitation with kainic acid (KA), a process that is calcium mediated and might have a role in physiologic neuronal excitation (267, 274)

Tian, J

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While this risk has not been confirmed in humans, it is something for patients and doctors to keep in mind