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j , Medium of WT and Smurf1 KO MEFs were quantified by the absorbance at 570 nm using microplate reader, and the standard curve of lactate concentration was calculated from samples containing certain concentrations of lactate (n = 3 independent experiments)

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The metanalysis includes 5,323 patients (56-61 years) with T2D inadequately controlled (HbA 1c 7-10.5%), baseline BMI 23-45 kg/m 2 , mean diabetes duration of 9-12 years, and randomized to receive a GLP-1RA or GIP/GLP-1RA versus placebo in add on to basal insulin for at least 24 weeks (24-40 weeks)

C57BL/6J mice (male, 68week-old) were acquired from China Medical University (Liaoning, China)