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It activates melanocortin receptors MC1R and MC3R, suppressing NF-kappaB nuclear translocation and consequently reducing pro-inflammatory cytokine production including TNF-alpha, IL-6, and IL-1beta

96 (17), e6723

Trends Mol Med 24(9):74862 Vallv-Juanico J, Santamaria X, Vo KC, Houshdaran S, Giudice LC (2019) Macrophages display proinflammatory phenotypes in the eutopic endometrium of women with endometriosis with relevance to an infectious etiology of the disease

This is largely due to their high sensitivity (0.90) but low specificity (0.20), which leads to a substantial number of unnecessary biopsies, as reported in reviews included in clinical practice guidelines

FP reports the receipt of grants/research support from AstraZeneca, Eisai, and Roche, and receipts of honoraria or consultation fees from Amgen, AstraZeneca, Daichii Sankyo, Celgene, Eisai, Eli Lilly, Exact Sciences, Gilead, Ipsen, Italfarmaco, Menarini, MSD, Novartis, Pierre Fabre, Pfizer, Roche, Seagen, Takeda, and Viatris, all outside the submitted work