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Other effects In addition to above effects, GLP-1R agonists have other neuroprotection mechanism on CNS, such as increasing the brain-derived neurotrophic factor (BDNF) levels and activity, regulating calcium homeostasis, promoting glycolysis, and reducing vascular damage

However, melanonychia is an ambiguous clinical finding that most commonly occurs as a result of benign etiologies such as nail matrix melanocytic activation, nail matrix melanocytic hyperplasia, and nail invasion by melanin-producing pathogens

How are GLP 1 & GIP Weight Loss Medications different from GLP 1 only therapies

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Dosing and risk reduction Some researchers believe that slower dose escalation and lower maintenance doses may reduce the risk of severe GI complications