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Descrito pela primeira vez em 1993 por Sikiri et al., apresenta notvel estabilidade qumica, mantendo a atividade biolgica mesmo no ambiente gastrointestinal cido uma propriedade que o distingue da maioria dos peptdeos teraputicos

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Always follow the manufacturer's recommended titration schedule in the SmPC, and consider extending the time at lower doses if patients experience significant gastrointestinal symptoms