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This inhibition mode in hTYR is noteworthy, as it suggests that the search for and optimization of efficient and safe peptide-based inhibitors may become a key direction in the development of human tyrosinase inhibitors

Hybrid-Rs may increase the functional pool of receptors capable of activating the IGF system and provide further growth advantages to a subset of cells over-expressing IGF-1R, IR-A, or both

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Nuclear factor kappa B (NF-B) and nuclear factor erythroid 2related factor 2 (Nrf2) represent two important signaling pathways in intestinal immune cells that regulate numerous physiological processes, including anti-inflammatory and antioxidant activities