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Genetically modified THP-1 are frequently utilised in the study of specific metabolic pathways, such as the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, whose assembly plays a central role in the innate immune response to nanoparticles [126]

Studies on the use of DBS for essential tremor highlight this point

109 YuasaK.OkuboK.YodaM.OtsuK.IshiiY.NakamuraM.et al (2018)

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To overcome these limitations, we propose that future strategies must prioritize lesion-focused drug delivery, such as nanocarriers and triggerable prodrugs, alongside biomarker-guided treatment regimens to decouple efficacy from systemic risk, paving a credible path for the clinical application of Erastin-class agents in EMS