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[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Dickinson D.A., Forman H.J

Apovian says these are compounded (custom-mixed) drugs brought in from other countries, with no oversight by the FDA, and no guarantee of what they contain

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391 However, systematic validation of safety profiles and synergistic mechanisms remains imperative before clinical implementation

1 DN is believed to be associated with neuronal, neuroglial cell and vascular endothelial cell injury caused by uncontrolled hyperglycemia, dyslipidemia and IR through multiple pathways, such as ERS, inflammation, oxidative stress and mitochondrial disorders