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Quantifying GLP-1 + cells in four mouse models of ileitis and colitis and characterizing two independent cohorts of each Tnf ARE mice and IL-10 -/- mice, we found a consistent reduction in GLP-1 expressing cells confined to the site of active disease and correlating to the degree of inflammation

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GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity) work through multiple mechanisms to control blood glucose and reduce appetite