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Funding This work was supported by grants from the National Natural Science Foundation (81972259, 82273394), the Clinical Trials Fund from Nanjing Drum Tower Hospital and the Affiliated Hospital of Nanjing University Medical School (2024-LCYJ-PY-01), Suzhou Municipal Health Commission (SKYD2022034), and the discipline construction and support project (XKTJ-JD202006) of the Second Affiliated Hospital of Soochow University

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