Inclusion of serial weight and standardised DXA measurements over 5 + years allowed us to study changes in body composition
The most notable is its capacity for substantial weight reduction, which may in turn confer downstream benefits including: Improved glycaemic control in individuals with type 2 diabetes Reduced cardiovascular risk factors such as hypertension and dyslipidaemia Potential improvement in hepatic steatosis , given the glucagon receptor component's proposed role in hepatic fat metabolism Possible improvements in physical function and quality of life associated with significant weight loss though these outcomes have not yet been formally established for retatrutide and require confirmation in Phase 3 trials As with all medicines in this class, retatrutide carries a recognised side effect profile
The newer development is understanding that glycine, not just cysteine, is also rate-limiting with age
But unlike natural GLP-1, which decays very rapidly (its half-life is just 2 minutes), synthetic GLP-1 receptor agonists are long-acting and remain active in your body for hours or days
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