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In this aspect, this comprehensive literature review aims to provide a holistic approach by critically summarizing and scrutinizing the potential molecular processes and mechanisms governing drugs and chemical transfer and metabolism across the placental barrier, which may lead to fetotoxicity effects, as well as analyzing the currently available experimental methodologies used to assess xenobiotics placental transfer and metabolism

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Mass spectrometry was performed on a Q Exactive Orbitrap (Thermo Fisher Scientific) with an Ion Max source and HESI II probe in positive and negative ionization modes (m/z 701000)

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