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Incretin therapies for NAFLD/NASH: Mechanisms and evidence

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Firstly, there is a reduced supply of N5-CH3-THF for the methylation of homocysteine, attributable to an adaptive increase in L-serine synthesis from glycine

Second, unlike previous NMA studies that reported statistical significance only for indirect outcomes such as laboratory data, this study extensively reviewed studies investigating the effects of GLP-1RA and TZD, the two most promising agents, using invasive and noninvasive technique-based outcomes