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Withdrawal increased anxiety-like behaviors, possibly linked to the upregulation of the GLP-1 pathway
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Previously, the GLP-1R agonist liraglutide has been shown to attenuate EMT changes in the UUO model by inhibiting TGF-1/Smad3 and ERK1/2 signaling pathways ( The present study in kidney transplantation model also indicates that TB001 significantly enhances lipid metabolism (marked by increased CPT1A expression in TECs) and reduces PKC- and PKC- expression, thereby attenuating kidney allograft fibrosis
"Reversal of obesity by targeted ablation of adipose tissue." Nature Medicine 10.6 (2004): 625-632
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