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For HIV, the mAb PGT121 binds to the V3-glycan site on the Env spike, which is distant from the site that binds the host cell receptor CD4, but this can allosterically inhibit binding of soluble CD4 and therefore may provide a neutralization mechanism 22

( Waly MI, Al-Attabi Z, Guizani N

Via the action of the methionine synthase reaction 5-methyl-THF is converted to THF

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